Objective:To study the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) gene + 49A/G polymorphism and the risk of periodontitis.Methods:A comprehensive literature research was electronically performed to retrieve currently published studies regarding the association of CTLA-4 gene +49A/G polymorphism with periodontitis susceptibility.The individual OR with 95％ CI was pooled to calculate the strength of the association using RevMan 5.2 software.Results:4 out of 18 seached studies satisfied the standard for Meta-analysis.A total of 702 cases and 926 controls were finally included in the Meta-analysis.Overall,no significant association of CTLA-4 gene + 49A/G polymorphism with the risk of periodontitis was observed (P ＞ 0.05).In the subgroup analysis by ethnicity,the results showed a significant association of CTLA-4 gene + 49A/G polymorphism with increased risk of periodontitis in Asian population(P ＜ 0.05) but not in Caucasian population(all P ＞ 0.05).The stratification analysis by subtypes of periodontitis revealed no significant association of the polymorphism with chronic and aggressive periodontitis respectively (all P ＞ 0.05).Conclusion:The present studies suggest that CTLA-4 gene + 49A/G polymorphism may be not associated with the risk of periodontitis in the overall population,but correlated with an increased risk of periodontitis in Asian population.%目的:探讨细胞毒性T淋巴细胞抗原4(CTLA-4)基因+49A/G多态性与牙周炎发病风险的关系.方法:计算机检索中英文数据库,收集出版的相关报道,以OR及其95％ CI为效应指标,应用RevMan 5.2软件进行Meta分析.结果:检出18篇文献,符合纳入标准的4篇文献包括患者702例,对照926例.Meta分析结果显示,CTLA-4基因+49A/G多态性与总体人群牙周炎易感性无明显相关性(P＞0.05).依种族进行亚组分析,该多态性与亚洲人群牙周炎易感性明显相关(P＜0.05),而在欧洲人群中无明显相关性(P＞0.05).根据牙周炎类型进行分层分析,该多态性与慢性及侵袭性牙周炎均无明显相关性(P＞0.05).结论:CTLA-4基因+49A/G多态性与总体人群牙周炎易感性无显著关联,但该基因多态性G等位基因可能是亚洲人群牙周炎的易感因子.
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