40 cases(control group)with aggressive periodontitis (AgP)received scaling and root planning (SRP)and 38 cases(test group)received SRP followed by oral administration of amoxicillin plus metronidazole for 7 d.Gingival crevicular fluid samples were exam-ined for the levels of MMP-1,MMP-8 and tissue TIMP-1 by ELISA before therapy,3 and 6 months after therapy,TIMP-1 /MMP-1 and TIMP-1 /MMP-8 ratios were calculated.The levels of MMP-1 and MMP-8 were decreased in both groups (P <0.05)at 3 and 6 months after therapy.TIMP-1 /MMP-1 and TIMP-1 /MMP-8 ratios were increased in the 2 groups(P <0.05)after treatment,3 months after therapy the ratio in test group was higher than that in control group(P <0.05).%对40例侵袭性牙周炎（AgP）患者（对照组）只行龈下刮治和根面平整术（SRP），对38例 AgP 患者（研究组）在行 SRP 基础上给予甲硝唑联合羟氨苄青霉素口服7 d。分别于治疗前、治疗后3个月和6个月用酶联免疫吸附法（ELISA）检测患者龈沟液中基质金属蛋白酶-1和8（MMP-1、MMP-8）及基质金属蛋白酶组织抑制物（TIMP-1）的浓度并计算 TIMP-1／MMP-1和 TIMP-1／MMP-8比值。治疗后3个月和6个月，2组患者龈沟液中 MMP-1、MMP-8浓度水平均下降（P ＜0．05），TIMP-1无显著变化（P ＞0．05）。治疗后2组患者龈沟液中 TIMP-1／MMP-1比值和 TIMP-1／MMP-8比值均明显升高（P ＜0．05），3月时研究组高于对照组（P ＜0．05）。
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