Objective:To investigate the clinical and pathological factors of metastasis in patients with oral squamous cell carcinoma (OSCC)and clinical lymph node-negative(cN0).Methods:85 patients of OSCC with cN0 treated in 2008-07 -2013-07 were inves-tigated retrospectively.Results:In the 85 patients 24(28.34%)showed occult metastasis.Patient's gender,lesion location had no im-pact to metastasis(P >0.05),the patient's age,tumor size,growth pattern and histopathologic grade showed significant influence on the metastasis of OSCC(P <0.05).Conclusion:The greater tumor volume,lower differentiation degree and young age are the factors of higher occult lymph node metastasis.Selective neck dissection treatments of OSCC is recommended.%目的：探讨颈部淋巴结阴性（cN0）的口腔鳞癌（OSCC）患者发生颈淋巴结隐匿性转移的规律和相关影响因素。方法：收集2008-07～2013-07接受颈淋巴结清扫的85例 cN0 OSCC 患者的临床和病理资料进行回顾性分析。结果：85例 cN0 OSCC患者中，总隐匿性转移率为28．24％（24／85）。cN0 OSCC 患者淋巴结转移率与性别、发病部位无相关性（P ＞0．05），与年龄、原发灶大小、病理分期及生长方式存在显著相关性（P ＜0．05）。结论：肿瘤体积越大、分化程度越低、患者年龄越小其淋巴结隐匿性转移率越高，对此类患者需积极行相应颈部淋巴结清扫处理。
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