目的:观察牙周基础治疗对2型糖尿病伴牙周炎(DMCP)患者血清中瘦素(leptin)的浓度、临床牙周状态、血糖控制的影响.方法:选取DMCP患者和不伴有全身系统性疾病的慢性牙周炎(CP)患者各30 例进行牙周基础治疗.分别在治疗前、治疗后1 个月和3 个月记录所有患者牙周临床指数:探诊深度(PD),附着丧失(AL)及菌斑指数(PLI),并检测血清中糖化血红蛋白(HbA1c)及leptin的含量.结果:DMCP组中PD、PLI和血清leptin含量在治疗后1 个月和3 个月时均显著降低(P<0.05),AL和血清HbAlc含量仅在治疗后3 个月显著降低(P<0.05).CP组中PD和PLI在治疗后1 个月和3 个月时均显著降低(P<0.05),AL和血清leptin含量仅在治疗后3 个月显著降低(P<0.05).2 组治疗前血清leptin含量与牙周临床指数呈正相关.结论:牙周基础治疗有助于DMCP患者的血糖控制、牙周状态改善和血清中leptin含量下降.%Objective: To study the effects of basic periodontal therapy on the serum leptin level and clinical periodontal measurements in type 2 diabetic patients with chronic periodontitis. Methods: 30 patients with type 2 diabetes and chronic periodontitis( DM-CP ) and 30 with chronic periodontitis( CP ) were enrolled. All subjects received basic periodontal therapy. Probing depth( PD ), attachment loss( AL ) and plaque index( PLI ) were recorded at baseline, 1 and 3 months after treatment. Glycated hemoglobin( HbAlc ) and the concentration of serum leptin were measured. Results: At 1 and 3 months after treatment, PD, PLI and the concentration of serum leptin were significantly reduced( P <0. 05 )in DMCP group, AL and the concentration of serum HbAlc reduced significantly 3 months after treatment ( P < 0.05 ). In CP group, PD and PLI significantly reduced( P < 0. 05 )l and 3 months after treatment, AL and the concentration of serum leptin reduced significantly 3 months after treatment ( P <0. 05 ). The serum leptin level was correlated with clinical periodontal parameters before treatment in both groups. Conclusion: The basic periodontal therapy is effective in the control of blood glucose level, improvement of clinical periodontal parameters and decrease of serum leptin level in DMCP patients.
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