The endometrium is one of the most fascinating tissues in the human body. Embryo implantation is a process that requires both temporal and spatial synchronization of the uterine endometrium and the embryo, and endometrium becomes receptive to the embryo during the window of implantation. Morphofunctional changes including sonography phenotype; pinopode, estrogen receptor(ER)and progesto-gen receptor(PR)expression in endometrial biopsy during this period may prevent or hinder the implantation. The expression patterns of many implantation-related molecules (such as integrin αvβ3, LIF, EGF, VEGF,ICAM-1,NO et al) change dynamically during this process. It becomes clear that overcoming the current bottleneck in improvements to assisted reproductive techniques will require a closer look at biomar-ker in the interface between uterus and embryo. Indeed, embryo implantation requires a cross talk with a receptive endometrium. We can learn more molecular markers related anatomical and functional of endometrial receptivity from the genomics and proteomics. This article reviews the potential marker which might be reflecting of endometrial receptivity.
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