Objective: To compare the clinical outcomes of elective single blastocyst transfer (SBT) with double cleavage embryo transfer(DET).Methods: Patients with good prognosis and high risk of multiple pregnancy (treatment cycle≤2,aged ≤38years,day 3 high quality embryo≥3,and normal endometrium)were divided into SBT group and DET group according to their patients' option. The implantation rate (IR) , clinical pregnancy rate(CPR)and multiple pregnancy rate(MPR)were compared between the two groups. Based on the above groundwork, we also compared the clinical outcomes of one SBT cycle plus one frozen cycle blastocyst transfer (FBT) (1SBT+1FBT)with those of one DET plus one FBT(1DET + 1FBT).Results: The IR in SBT group was significantly higher than that in DET group(52. 4% vs. 43. 4%, P＜0. 05),while the CPR(52. 4% vs. 60. 1% , P＜0. 05) was significantly lower in SBT group compared with DET group. However, patients in the SBT group had a significantly lower multiple pregnancy rate compared with DET group(P＜0. 05). There was no significant difference in the cumulative pregnancy rate between the 1SBT+1FBT group and the 1DET+1FBT group (76. 8% vs. 80. 4% , P＞0. 05) , but the multiple pregnancy rate was significantly lower in the former(4. 9% vs. 37. 8%,P＜0. 05).Conclusion: The higher implantation rate with similar cumulative pregnancy rate is obtained in SBT group. The SBT is proposed to be an effective method for significantly reducing the risk of multiple pregnancies without compromising the clinical pregnancy rate.
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