Objective: To study the effects of mifepristone on collagen type IV and fibronectin in human decidua during first trimester of pregnancy for further investigating the mechanisms of antigestational action of mifepristone.rn Methods: Fifty-five women with early pregnancy (≤60 gestational days) were divided into treatment group (mifepristone 150 mg administered) and control group randomly. Immunohistochemical technique (ABC method) was carried out to examine the distribution of collagen type IV and fibronectin in decidua of both groups.rn Results: Compared with control group, the levels of decidual collagen type IV and fibronectin in treatment group were significantly decreased (P<0.01,P<0.05).Particularly, the contents of collagen type IV in glandular basal membrane and the fibronectin in extracellular matrix (ECM) were significantly reduced (P<0.01).rn Conclusion: The results suggested that the anti-gestational effect of mifepristonemay act through decreasing the decidual collagen type IV and fibronectin. The concen-trations of these two componentes in ECM of decidua might be related by progesterone and corticosteroid.%目的：探讨米非司酮(Ru 486)对早孕蜕膜组织中IV型胶原、纤维粘连蛋白(FN)的影响，进一步认识米非司酮的抗早孕机理。方法：孕<60 d妇女，随机分为对照组和药物组。药物组口服米非司酮总量为150 mg。采用免疫组织化学(ABC)法测定早孕蜕膜组织IV型胶原(对照组15例，药物组20例)和纤维粘连蛋白(对照组25例，药物组30例)的分布状况。结果：与对照组相比，药物组早孕蜕膜组织中IV型胶原、FN均明显减少(P<0.01,P<0.05)。尤其是 IV型胶原在腺体基膜，FN在蜕膜细胞间质中降低最为明显(P<0.01)，上皮基膜、血管周围IV型胶原含量也明显降低(P<0.05)。结论：米非司酮明显影响早孕蜕膜组织中这两种细胞外基质(ECM)的含量及分布，可使IV型胶原、FN的含量减少，而起到抗早孕作用。早孕蜕膜组织中这两种ECM成分可能受孕激素及糖皮质激素的调控。
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