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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Elevated expression levels of matrix metalloproteinase-9 in placental villi and tissue inhibitor of metalloproteinase-2 in decidua are associated with prolonged bleeding after mifepristone-misoprostol medical abortion
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Elevated expression levels of matrix metalloproteinase-9 in placental villi and tissue inhibitor of metalloproteinase-2 in decidua are associated with prolonged bleeding after mifepristone-misoprostol medical abortion

机译：米非司酮-米索前列醇药物流产后胎盘绒毛中基质金属蛋白酶9表达水平升高和蜕膜组织金属蛋白酶2组织抑制剂水平升高与出血时间延长有关

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Objective To determine whether the expression levels of matrix metalloproteinases 2 and 9 (MMP-2 and -9) and tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2) in the villi and the decidua are associated with prolonged bleeding after medical abortion. Design Case-controlled study. Setting University hospital. Patient(s) Mifepristone-misoprostol medical abortion patients were divided into two groups (20 women each) based on the length of time (>14 or ≤14 days) of bleeding after the abortion. Intervention(s) Discharged villi and deciduas were collected. Main Outcome Measure(s) The expression levels of MMP-2 and -9 and TIMP-1 and -2 in the villi and deciduas were assessed with semiquantitative immunohistochemistry. Result(s) The median semiquantitative immunohistochemistry staining index (SI) scores for MMP-9 expression in the villi were elevated in the bleeding group compared with the control group (median SI scores 0.31 and 0.03, respectively). TIMP-2 expression was elevated in the decidua in the bleeding group compared with the control group (median SI scores 1.00 and 0.20, respectively). No significant differences were observed between the two groups in the expression levels of MMP-2 in the villi or of MMP-2, MMP-9, or TIMP-1 or of the ratios of MMP-9/TIMP-1 or MMP-2/TIMP-2 in the decidua. Conclusion(s) Elevated expression levels of MMP-9 in the villi and of TIMP-2 in the decidua were associated with prolonged bleeding after medical abortion.
机译：目的确定绒毛和蜕膜中基质金属蛋白酶2和9（MMP-2和-9）和金属蛋白酶1和2的组织抑制剂（TIMP-1和-2）的表达水平是否与药物治疗后长时间出血有关流产。设计案例对照研究。设置大学医院。米非司酮-米索前列醇药物流产患者根据流产后出血的时间长度（> 14天或≤14天）分为两组（每组20名妇女）。干预措施收集排出的绒毛和蜕皮。主要结果指标用半定量免疫组织化学方法评估绒毛和蜕皮瘤中MMP-2和-9以及TIMP-1和-2的表达水平。结果出血组绒毛中MMP-9表达的中位半定量免疫组织化学染色指数（SI）得分高于对照组（中位数SI得分分别为0.31和0.03）。与对照组相比，出血组蜕膜中TIMP-2表达升高（SI平均值分别为1.00和0.20）。两组之间在绒毛中的MMP-2或MMP-2，MMP-9或TIMP-1的表达水平或MMP-9 / TIMP-1或MMP-2的比率方面均未观察到显着差异。 / TIMP-2在蜕膜中。结论药物流产后绒毛中MMP-9和蜕膜中TIMP-2的表达水平升高与出血时间延长有关。

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