目的：通过分析女童病因不明的反复外阴阴道炎（ RVV）过敏原特点、过敏家族史和过敏相关疾病的关系，探讨女童RVV的发生与过敏的相关性。方法：采用前瞻性病例对照研究，选择病因不明的200例青春期前RVV患者为观察组，同期参加健康查体、年龄相仿的200例健康女童为对照组，两组均行过敏原血清特异性IgE测定，记录过敏相关疾病及家族史。结果：观察组过敏原阳性率以及过敏家族史、吸入过敏、食物过敏的阳性率均明显高于对照组（ P＜0.001）。观察组中有过敏家族史者sIgE阳性组远高于sIgE阴性组（ P＜0.001），合并湿疹、鼻炎、哮喘等过敏性疾病者阳性组远高于阴性组（ P＜0.001）。结论：女童RVV与过敏体质有关，虽然这种关系的确切机制还有待研究，但过敏体质可能是RVV致病和（或）发病的促进因素。%Objective:To investigate associations between allergy and recurrent vulvovaginitis of undetermined etiology( RVV) of girls by analyzing the characteristics of their allergens, familial history of atopy, and allergy-related diseases.Methods:After being investigated by pediatric gynecologists, 200 patients with RVV who were considered to have undetermined etiology formed the study group.The control group consisted of 200 healthy girls. Study and control groups were investigated for atopy by means of serum specific IgE.Associated allergic diseases and familial atopy histories of the subjects were recorded.Results: The rate of atopy in the study group was significantly higher than in the control group ( P <0.001 ) .Familial history of atopy, inhaled allergens, food allergies all significantly increased the chance of positive sIgE in the study group than in the controls( P<0.001) . sIgE positive patients also tended to have higher rates of familial history of atopy and allergic diseases including eczema, rhinitis, asthma, etc.( P<0.001 ) .Conclusion: Girls'RVV is associated with allergy.Although the exact mechanism( s) of this relationship remains to be investigated, allergy might be a cause and( or) contributing factor in the pathogenesis of RVV.
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