Objective To investigate peripheral blood apelin levels in patients with acute ST-elevation myocardial infarction (STEMI) and their correlation with the one-year outcome of the patients. Methods A total of 153 consecutive patients, including 93 with acute STEMI undergoing primary percutaneous coronary intervention (PCI), 30 with acute STEMI and 30 with stable angina all undergoing elective PCI, and 10 healthy control subjects were examined for peripheral blood apelin levels and clinical parameters. The composite endpoints (CEPs) were determined at the one year follow-up. Results Apelin levels were significantly decreased in all the patients at admission, but increased following primary PCI. Apelin levels showed a negative correlation with glycosylated hemoglobin levels. At one year following PCI, the patients with a lower apelin level showed an increased risk for lowered left ventricular ejection fraction ratio, but further analysis failed to provide evidence that apelin levels were predictive of the one-year outcome. Conclusion Peripheral blood apelin levels might be useful for predicting the clinical outcomes of patients with acute STEMI.%目的：探讨急性ST段抬高型心肌梗死患者apelin水平变化的意义与一年预后的关系。方法测定93位接受直接PCI的STEMI患者、30位接受择期PCI的STEMI患者、30位接受择期PCI的稳定型心绞痛患者及10位健康志愿者不同时段外周血apelin水平，同时收集相应的临床资料。行冠脉造影术后予以Gensini评分。在患者入院时及随访一年（或终点事件）时评估左室射血分数（LVEF）。结果 STEMI患者外周血apelin水平降低，直接PCI后apelin水平上升，差异有统计学意义；择期PCI的STEMI患者PCI术后apelin水平无显著变化，且低于接受直接PCI的患者；apelin水平与糖化血红蛋白负相关；一年随访表明， apelin水平降低与低LVEF相关，但难以预测一年终点事件。结论外周血apelin可能为急性ST段抬高型心肌梗死即时及预后的参考指标。
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