Objective To investigate the prevalence and risk factors of postpartum depression (PPD) in Tianhe district of Guangzhou. Methods A total of 1428 postpartum women in 3 hospitals in Tianhe District of Guangzhou were screened with Edinburg Postnatal Depression Scale (EPDS), Social Support Rating Scale (SSRS) and a self-designed questionnaire of PPD-related factors during the period from May to September, 2013. Results The prevalence of PPD was 20.03%in these women. Unconditional logistic regression analysis showed a significant correlation of PPD with education, delivery mode, only daughter, relationship between mother-in-law and daughter-in-law, newborn gender satisfaction and housing condition (P<0.05). Multivariate logistic regression analysis identified education, delivery mode, only daughter, relationship between mother-in-law and daughter-in-law, and newborn gender satisfaction as the risk factors for PPD, and housing condition was negatively correlated with the incidence of PPD with an OR value of 0.900. Compared with healthy postpartum women, the patients with PPD exhibited significantly reduced total score of social support rating scale, score of objective support, score of subjective support, and social utilization degree. Conclusion The prevalence of PPD is high in Tianhe District of Guangzhou, and health education and psychosocial intervention should be offered to prevent PPD.%目的：了解广州市天河区产后抑郁症（PPD）的发生率及相关危险因素，为PPD的防治提供依据。方法采用爱登堡产后抑郁量表（EPDS）、社会支持评定量表（SSRS）及PPD影响因素调查表对广州市天河区3家医院2013年5月~2013年9月分娩的1428名产妇进行调查。结果1428名产妇中，PPD发生率为20.03%，非条件Logistic回归分析显示文化程度、分娩方式、独生女产妇、婆媳关系、家人对新生儿性别满意度、住房面积等6个因素与PPD的关系有统计学意义（P<0.05）；多因素Logistic回归分析显示文化程度、分娩方式、独生女产妇、婆媳关系、家人对新生儿性别满意度是PPD的危险因素，住房面积与PPD呈负相关， OR值为0.900；产后抑郁组SSRS总分、主观支持分、客观支持分、对支持利用度均低于正常组（P<0.05）。结论广州市天河区PPD发生率较高，应加强对产妇及其家庭的健康教育，加强社会因素干预，防治PPD的发生。
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