目的探讨乳腺癌p21WAF1／CIP1基因的表达与激素受体、肿瘤分级、淋巴结转移的关系。方法应用免疫组化SP法对60例乳腺癌组织p21WAF1／CIP1基因及雌孕激素受体表达进行同时检测。结果 p21WAF1／CIP1、雌激素受体(ER)及孕激素受体(PR)阳性率分别为50％、55％、48％。p21WAF1／CIP1基因表达与ER、PR相关，并随着乳腺癌恶性程度增加和淋巴结转移阳性率降低。结论检测p21WAF1／CIP1在乳腺癌的表达，对指导乳腺癌内分泌治疗和评估肿瘤生物学行为有重要意义。%Objective To investigate the relationship between p21WAF1/CIP1 protein and ER, PR and histologic grade as well as lymph node metastasis in human breast cancer. Methods By us ing immunohistochemical method, the expression of p21WAF1/CIP1, ER and PR was investigated in 60 breast carcinoma samples. Results It was noted that a significant correlation existed between p21WAF1/CIP1 and ER、PR、p21WAF1/CIP1 expression was related to histologic grade and lymph node metastasis. Conclusion ①Detection of p21WAF1/CIP1 protein may have important reference value for patients with breast cancer to receive endocrine therapy; ②)p21WAF1/CIP1 protein expression is of value in evaluating the degree of differentiation and lymph node metastasis of breast cancer
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