The area of Yan227 on Shengli Oilfield is located on the higher position of sandyconglomerate of the north steep slope tectonic zone of Yan227 well on the Dongying hollow of Jiyang Depression. In this article,the functions and applications of Organic Amine Strong Inhibition Drilling Fluid System which take the Organic Amine Inhibitor,namely WAN-1,as the main treatment agent is estimated in order to solve some complex issues such as swelling because of hydration and collapse of mudstone on the Yan227 Area of Shengli Oilfield.This research shows that, WAN-1 inhibits the process from clay to slurry effectively, limits the capacity of clay. The use of WAN-1 inhibits the hydration and dispersion of shale effectively, and it is stable at high temperature. Organic Amine Strong Inhibition Drilling Fluid has similar ability of restraining the expansion and dispersion of cuttings as Oil Base Drilling Dluid System,the System will be used to stabilize the borehole preferably,improve the mechanical drilling speed and shorten the drilling cycle. It can not surmount the common method of adding a largh number of crude oil for enhance lubricating property in the current,so we need to research the technology which is similar to oil-base mud in order to reduce the friction resistance more effectively in future.%盐227-3HF井是一口非常规水平井，上部地层泥岩蒙脱石含量高，沙三段、沙四上上部砂泥互层易垮塌；沙三下和沙四上纯上亚段泥岩微裂缝及层理发育，极易发生坍塌掉块，造成起下钻阻卡、憋泵，钻井液技术难度大。使用有机胺强抑制钻井液体系，配合现场钻井液维护处理工艺，施工井壁稳定，解决了泥页岩地层水化垮塌的难题，提高了机械钻速，缩短了钻井周期。
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