Objective To study the relationship between the expression of IL-17RA and prognosis in Non-Small-Cell Lung Cancer.Methods 131 patients who had surgical resection and had with neither radiother-apy nor chemotherapy before operation were collected.Envision Immunohisto-chemistry analysis was used to detect the expression of IL-17RA in lung carcinoma tissues and surrounding tissues.The effect of IL-17RA expression on the 3a disease-free survival of patients (Disease-free survival,DFS)were analyzed with Kaplan-Meier method.Results The positive expressions of IL-17RA in lung carcinoma tissues were significantly higher than those in the peritumor tissues (P <0.001).In the univariate analysis,the expres-sion rate of IL-17RA was statistically different with the pathological type tumor size staging and P TNM staging (P <0.05).The Disease-free survival rate of patients was different between positive and negative IL-17RA expression (P =0.032)in lung carcinoma tissues.Cox multivariate analysis showed that the ex-pression level of IL-17 were independent prognostic factors (P = 0.041,HR= 1.683).Conclusion This study showed that IL-17RA expression of tumor tissue associated with poor prognosis.%目的：研究白细胞介素17受体 A（Interleukin-17 receptor type A，IL-17RA）在非小细胞肺癌中的表达及其与预后的关系。方法收集2010年1月1日－2013年12月31日在新疆医科大学附属肿瘤医院胸外科接受标准肺癌根治术且随访资料完整的131例肺鳞癌和腺癌患者的术后标本，采用免疫组织化学法检测癌组织、癌旁组织中 IL-17RA 的表达情况。Kaplan-Meier 法比较癌组织 IL-17RA 高表达和低表达对患者3年无病生存期（Disease-free survival，DFS）的影响。结果IL-17RA 在癌组织的表达高于癌旁组织（P ＜0．001）；IL-17RA 的表达与病理类型、肿瘤直径和术后病理分期（pTNM stages，pTNM）有关（P ＜0．05）；生存分析显示，癌组织 IL-17RA低表达患者的 DFS 均优于 IL-17RA 高表达者（P ＝0．032）；COX 回归分析结果显示，IL-17RA 阳性表达是肺鳞癌、腺癌患者 DFS 的重要影响因素（P ＝0．041，HR＝1．683）。结论IL-17RA 表达是非小细胞肺癌患者独立预后因素，高表达提示预后差。
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