Objective To investigate the correlation between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features and the prognosis and pathological classification of breast cancer.Methods Forty patients with breast cancer were proved by DCE-MRI and pathological examination in the Third Affiliated Hospital of Xinxiang Medical University from January to December 2016.The DCE-MRI features,estrogen receptor (ER),progesterone receptor (PR),human epidermal growth factor receptor-2 (Her-2) and the pathological classification of breast cancer were collected.The correlation between DCE-MRI features and molecular biology indexes in breast cancer was analyzed by Spearman rank correlation analysis.Results There was no significant correlation between the lesion size and the positive expression rate of ER,PR and Her-2 (r =-0.119,0.063,0.237;P ＞ 0.05).The lesion morphology was positively correlated with the positive expression rate of Her-2(r =0.296,P ＜ 0.05) but there was no significant correlation between the lesion morphology and the expression of ER and PR (r =0.219,0.211;P ＞ 0.05).The lesion enhancement form was negatively correlated with PR positive expression (r =-0.304,P ＜ 0.05),and it was not correlated with the expression of ER and Her-2 (r =0.396,-0.393;P ＞ 0.05).There was no significant correlation between the TIC type of the lesion and the expression of ER,PR and Her-2 (r =0.254,0.315,0.396;P ＞0.05).The early enhancement rate was positively correlated with Her-2 positive expression (r =0.498,P ＜ 0.05),but there was no correlation between early enhancement rate and the expression of ER and PR(r =0.125,0.241;P ＞ 0.05).The lesion morphology,enhancement and early enhancement rate of the lesion were significantly correlated with the pathological type of breast cancer (r =0.399,0.323,0.513;P ＜ 0.05).The lesion size and the TIC type were not significantly correlated with the pathological type of breast cancer (r =0.313,0.308;P ＞ 0.05).Conclusion The shape,edge and enhancement form of lesion in DCE-MRI are correlated with the prognosis and pathological types of breast cancer;which provides a theoretical basis for the evaluation of biological behavior,prognosis and severity of breast cancer through the imageology.%目的 探讨动态增强磁共振成像(DCE-MRI)特征与乳腺癌预后和病理分型的相关性.方法 收集新乡医学院第三附属医院2016年l～12月行DCE-MRI检查并经手术病理证实为乳腺癌的患者40例,分别统计分析MRI图像特征及雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(Her-2)等预后相关分子生物学指标以及病理分型,采用Spearman等级相关分析乳腺癌DCE-MRI表现特征与分子生物学指标的相关性.结果 病变直径与ER、PR、Her-2阳性表达率无显著相关性(r=-0.119、0.063、0.237,P＞0.05).病变形态与Her-2阳性表达率呈显著正相关(r =0.296,P＜0.05),与ER、PR的表达无显著相关性(r=0.219、0.211,P＞0.05).病变强化形式与PR阳性表达率呈负相关(r=-0.304,P＜0.05),与ER、Her-2表达无相关性(r=0.396、-0.393,P＞0.05).病变TIC类型与ER、PR、Her-2的表达均无显著相关性(r=0.254、0.315、0.396,P＞0.05);而早期增强率与Her-2阳性表达率呈显著正相关(r=0.498,P＜0.05),与ER、PR的表达无相关性(r=0.125、0.241,P＞0.05).病变形态、强化形式及早期强化率与乳腺癌的病理分型存在显著正相关(r=0.399、0.323、0.513,P＜0.05);而病变直径、TIC类型与乳腺癌的病理分型无显著相关性(r =0.313、0.308,P＞0.05).结论 DCE-MRI图像病变形态及强化形式与乳腺癌预后相关指标和病理分型存在一定相关性,为从影像学角度评估乳腺癌的生物学行为、预后及病情严重程度等提供了理论依据.
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