[目的]根据对LINGO-1在中枢神经系统疾病的相关信息进行了收集和分析，对其研究近况进行了综述。[方法]结合当前治疗中枢神经系统损伤性疾病的热点，总结LINGO-1的生理功能及在中枢神经系统损伤性疾病中的研究进展。[结果] LINGO-1是一种跨膜蛋白，在中枢神经系统（CNS）中有特异性表达，研究表明它对轴突再生和少突胶质细胞的增殖、成熟与髓鞘化等均有明显的抑制作用。[结论]进一步明确LINGO-1可作为促进轴突再生的有效新靶点。% [Objective]According to the col ection and analysis on the information concerning present LINGO-1 in the central nervous system damage, it makes review on the study on LINGO-1. [Method] With the current treatment of central nervous system damage in disease hot spots, this article summa-rizes the research progress of the physiological function of LINGO-1 disease in the central nervous system damage. [Result] LINGO-1 is a transmembrane protein, the specific expression in CNS; studies have shown that it is axonal regenerationand oligodendrocyte proliferation, mature and myelination signifi-cantly inhibited. [Conclusion] Further clarifying the LINGO-1 can be used as effective new target to promote axonal regeneration.
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