采用行为观察和生化检测方法,研究了饮食限制58 d对小鼠学习记忆的影响及其各组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的变化．结果显示:限食小鼠在新环境中更显得不安,66.7%饮食限制组小鼠记忆能力最弱而空间识别能力最强,40%饮食限制组小鼠学习能力最强;限食小鼠各器官的脏器系数相比自由饮食组都有所升高;各组小鼠所测器官的SOD活性没有明显的区别,但心、肾和脑中MDA含量随饮食限制水平的升高而增高.提示饮食限制对机体器官有一定的损伤作用,适当饮食限制能提高学习能力,但对抗氧化能力的影响不明显.%The effects of dietary restriction on learning-memory of mice, the activity of superoxide dismutase ( SOD ) and the content of malonaldehyde ( MDA ) were investigated through behavior observation and biochemistry analysis. Compared with the control group, the results were as follows: the dietary restriction mice were in tranquil in new environment, and 66.7％ DR group had the weakest memory, while with the spatial identification strongest. The leaning capacity of 40％ DR group was strongest. The organ coefficient increased compared with free diet group. The activity of SOD was not significant, while the content of MDA in brain, kidney and heart increased. It implied that dietary restriction had a certain effect on organ damage, appropriate dietary restriction could improve leaning capacity but had an inconspicuous effect on antioxidant capacity.
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