目的 探讨血清抗苗勒激素(AMH)及抑制素B(INHB)与多囊卵巢综合征(PCOS)患者性激素的关系及其应用价值.方法 选取2015年6月至2016年6月120例PCOS患者(PCOS组)及100例健康体检者(对照组),分别于月经第3天抽取静脉血3 mL测定两组AMH、INHB及性激素水平,采用受试者工作特征曲线(ROC)分析血清AMH、INHB在PCOS诊断中的价值.结果 PCOS组血清AMH、INHB、卵泡刺激素(FSH)、睾酮(T)、黄体生成素(LH)水平显著高于对照组(P<0.05),而雌二醇(E2)水平低于对照组(P<0.05).经Pearson相关分析可知,AMH与T、LH呈正相关,而与E2负相关(P<0.05),而INHB与T呈正相关(P<0.05),而与E2呈负相关(P<0.05).AMH、INHB诊断PCOS的ROC曲线下面积(AUC)为0.828,0.810;AMH诊断PCOS灵敏度、特异度分别为81.12%、80.39%,INHB诊断PCOS灵敏度、特异度分别为78.12%、75.39%.结论 PCOS患者血清AMH、INHB明显高于健康女性,且与激素水平有密切的关系,可能与激素合成失调有关,测定血清AMH、INHB水平将可有助于PCOS诊断.%Objective To investigate the relationship between serum anti-Mullerian hormone(AMH),inhibin B(INHB) and sex hormones in patients with polycystic ovary syndrome(PCOS).Methods A total of 120 patients with PCOS and 100 cases of he-althy controls(control group) were selected from June 2015 to June 2016.The levels of AMH,INHB and sex hormones were measured in 3 mL of menstrual blood on the 3rd day of menstruation.The value of serum AMH and INHB in the diagnosis of PCOS were analyzed with receiver operating characteristic(ROC) curve.Results The levels of AMH,INHB,FSH,T,LH in PCOS group were significantly higher than those in the control group(P<0.05),while E2 level was lower than that in the control group(P<0.05).Pearson correlation analysis showed that AMH was positively correlated with T and LH and negatively correlated with E2,while INHB was positively correlated with T(P<0.05),but negatively correlated with E2(P<0.05).AUC of AMH and INHB were 0.828 and 0.810,respectively.The sensitivity and specificity of AMH in diagnosing PCOS were 81.12% and 80.39% respectively.The sensitivity and specificity of INHB in diagnosing PCOS were 78.12% and 75.39%,respectively.Conclusion The levels of serum AMH and INHB in patients with PCOS are significantly higher than those in healthy women.The serum levels of AMH and INHB are closely correlated with the levels of hormone,which may be helpful to the diagnosis of PCOS.
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