Objective To systematically evaluate the association between rs895819 polymorphism of microR‐NA miR‐27a and the susceptibility of breast cancer .Methods A computer‐based retrieval of PubMed ,EMBASE ,Co‐chrane Library ,CBM ,VIP ,CNKI and Wanfang Database from their establishment to June 2014 was performed for collecting the case‐control studies investigating the miR‐27a polymorphisms and the susceptibility of breast cancer published at home and abroad .The literature was screened according to the inclusion and exclusion criteria and the quality of studies was evaluated .Then the data were performed the Meta‐analysis by using RevMan 5 .2 software .Re‐sults 5 articles were included ,in which 2 articles were the study on European populations and 3 articles were the study on Asian populations .The Meta analysis showed that the miR27a rs895819 polymorphism had no relation with the breast cancer susceptibility in the total populations and Asian populations ,but the 3‐model analysis in the Europe‐an populations indicated that the miR27a rs895819 polymorphism was related with the breast cancer susceptibility , which were allele model G vs .A(OR=0 .89 ,95CI% :0 .82 -0 .97 ,P=0 .008) ,codominant model AG vs .AA(OR=0 .83 ,95% CI:0 .74-0 .94 ,P=0 .002)and dominant model GG+ AG vs .AA (OR=0 .83 ,95% CI:0 .75 -0 .91 ,P=0 .002)respectively .Conclusion The existing evidences reveal that the rs895819 polymorphism of the miR‐27a is not found to be associated with the susceptibility of breast cancer in total populations and Asian populations .However the rs895819 polymorphism of miR‐27a is associated with the susceptibility of breast cancer in European populations .%目的：系统评价不同人群中微小RNAmiR‐27ars895819多态性与乳腺癌易感性的关系。方法计算机检索PubMed、EMBASE、CochraneLibrary、中国生物医学文献数据库（CBM）、中文科技期刊全文数据库（VIP）、中国期刊全文数据库（CNKI）及万方数据库，收集国内外发表的关于miR‐27a基因多态性与乳腺癌易感性的病例对照研究。检索时间均从建库至2014年6月，按纳入和排除标准筛选文献并评价纳入研究质量后，应用RevMan5．2软件进行Meta分析。结果该研究共纳入5篇文献，其中2篇在欧洲人群中进行研究，3篇在亚洲人群中进行研究。Meta分析结果显示：在总体人群与亚洲人群中miR‐27ars895819多态性与乳腺癌易感性无关，而在欧洲人群中有3个模型分析表明miR‐27ars895819多态性与乳腺癌易感性有关，分别为等位基因模型Gvs．A（OR＝0．89，95CI％：0．82～0．97，P＝0．008）；共显性模型AGvs．AA（OR＝0．83，95％CI：0．74～0．94，P＝0．002）；显性模型GG＋AGvs．AA（OR＝0．83，95％CI：0．75～0．91，P＝0．002）。结论在总体人群及亚洲人群中miR‐27rs895819多态性与乳腺癌易感性无关。然而在欧洲人群中miR‐27rs895819多态性与乳腺癌易感性有关。
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