目的 探讨血脂代谢与氧化应激在精神分裂症中的关联.方法 测定50例精神分裂症患者及49名体检健康者(正常对照组)血清总胆固醇(TC)、甘油三酯(TG)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、丙二醛(MDA).将TC>5.72 mmol/L和TG>1.7 mmol/L定义为血脂水平升高,TC或TG中有1项正常的患者不纳入分组,按此标准将精神分裂症患者分为血脂正常组(24例)和高血脂组(17例).结果 与正常对照组比较,精神分裂症组血清TC、TG、MDA水平明显升高(P<0.05),血清SOD、GSH水平明显降低(P<0.05).血脂正常组与高血脂组之间血清SOD、GSH、MDA水平差异均无统计学意义(P>0.05).结论 精神分裂症患者存在诱发心血管疾病的血脂异常,且有氧化应激损伤,但血脂异常和氧化应激与精神分裂症的关系有待进一步研究.%ObjectiveTo investigate the relationship between oxidative stress and blood lipid metabolism in schizophrenia.MethodsSerum total cholesterol(TC),triglyceride(TG),superoxide dismutase(SOD), glutathione(GSH) and malondialdehyde(MDA) were determined in 50 patients with schizophrenia and 49 healthy subjects(healthy control group). Serum TC>5.72mmol/L and serum TG>1.7 mmol/L meant blood lipid levels elevated,patients who had normal serum TC or normal serum TG were excluded,and schizophrenia patients were classified into normal blood lipid group(24 cases) and hyperlipemia group(17 cases).ResultsComparing with healthy control group,serum levels of TC,TG and MDA in schizophrenia group were higher(P<0.05), serum SOD and GSH levels decreased(P<0.05). The serum levels of SOD,GSH and MDA between normal blood lipid group and hyperlipemia group had no statistical significance(P>0.05).ConclusionsSchizophrenia patients have dyslipidemia inducing cardiovascular diseases and oxidative stress injury. The relationship between oxidative stress and blood lipid metabolism in schizophrenia should be researched further.
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