目的 评价缺铁性贫血(IDA)和β地中海贫血(β-TT)的鉴别诊断公式在四川自贡地区人群中的应用价值.方法 选取760例来自四川自贡地区患者,其中β-TT 255例、IDA505例,应用红细胞(RBC)参数计算出10个鉴别公式(分别为Shine and Lal公式、Green and King公式、Mentzer公式、RDWI公式、Srivastava公式、Ricerca公式、England and Fraser公式、Ehsani公式、Sirdah公式和Huber-Herklotz公式)的敏感度(SEN)、特异度(SPE)、阳性预测值(PPV)、阴性预测值(NPV)、约登指数(YI),并绘制受试者工作特征(ROC)曲线.结果 Mentzer公式的诊断价值最高,其YI最高(80.1％),诊断IDA的SEN为97.0％,SPE为83.1％,曲线下面积(AUC)最高(0.971);其次为RDWI公式,YI、SEN、SPE、AUC分别为72.8％、95.2％、77.6％、0.961.结论 在四川自贡地区人群中Mentzer公式和RDWI公式具有较好的鉴别诊断IDA和β-TT的能力.%ObjectiveTo evaluate discrimination formulas for the differential diagnosis of iron deficiency anemia(IDA) and beta thalassemia trait(β-TT) in Sichuan Zigong.MethodsA total of 760 patients from Zigong were enrolled,including 255 cases ofβ-TT and 505 cases of IDA. Red blood cell(RBC) indices were used to calculate the sensitivities(SEN),specificities(SPE),positive predictive values(PPV),negative predictive values(NPV),and Youden's indices(YI) of 10 discrimination formulas,including Shine and Lal,Green and King, Mentzer,RDWI,Srivastava,Ricerca,England and Fraser,Ehsani,Sirdah and Huber-Herklotz. Receiver operating characteristic(ROC) curve was drawn.ResultsMentzer was the most reliable index,as it had the highest YI(80.1％),the SEN was 97.0％,the SPE was 83.1％,and area under curve(AUC) was 0.971. The YI,SEN,SPE and AUC for RDWI were 72.8％,95.2％,77.6％ and 0.961,respectively.Conclusions Mentzer and RDWI can be used for the differential diagnosis fo IDA andβ-TT.
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