Objective:To explore the effect of ACEI/ARB for patients with hypertension complicated with atrial fibrillation (AF) on level of serum hs-CRP and its clinical significance. Methods: 85 patients with hypertension complicated with AF were classified as AF group, 54 patients with hypertension and sinus rhythm (SR) were classified as SR group,and both divided into SR without ACEI/ARB treatment group (n=26)and SR with ACEI/ARB treatment group(n=28), AF without ACEI/ARB treatment group(n=42) and AF with ACEI/ARB treatment group(n=43) according to with or without ACEI/ARB therapy. The levels of serum hs-CRP were compared among the three groups. Results: The level of serum hs-CRP in AF without ACEI/ARB treatment group was significantly higher than that in the SR without ACEI/ARB treatment group (P < 0.05),there was no significantly different between with and without ACEI/ARB treatment group (P > 0.05). The level of serum hs-CRP in AF with ACEI/ARB treatment group was significantly lower than that in the AF without ACEI/ARB treatment group (P < 0.05). Conclusions: The serum hs-CRP increases in patients with hypertension complicated with AF,and it may reduce after ACEI/ARB treatment.%目的：探讨 ACEI／ARB 治疗对高血压伴心房颤动（ AF ）患者血清 hs－CRP 的影响及其临床意义。方法：以高血压并 AF 的85例患者为房颤组，高血压、窦性心律的54例患者为窦律组，按是否接受 ACEI／ARB治疗分成窦律非治疗组26例、窦律治疗组28例、房颤非治疗组42例和房颤治疗组43例，比较各组血清 hs－CRP。结果：房颤非治疗组血清hs－CRP显著高于窦律非治疗组（P ＜0．05）；窦律组内血清hs－CRP差异无统计学意义（P ＞0．05）；房颤治疗组血清hs－CRP 明显低于房颤非治疗组（P ＜0．05）。结论：高血压伴房颤患者血清 hs－CRP升高，ACEI／ARB治疗可降低其hs－CRP 水平。
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