Objective: To explore the effect of patients with acute organophosphorus pesticides poisoning (AOPP) treated by Penehyclidine Hydrochloride combining Atropine and Pyraloxime Methylchloride. Methods: 108 patients with AOPP were divided randomly into control group (n=59) and observation group (n=59), and accepted treatment of Atropine and Pyraloxime Methylchloride,Penehyclidine Hydrochloride combining Atropine and Pyraloxime Methylchloride respectively. The recovery time of ChE and stay in-hospital and fatality rate were compared between the two groups. Results:The recovery time of ChE and stay in-hospital and fatality rate were significantly lower in the observation group than those in the control group (P < 0.05). Conclusion: Compared with the treatment of Atropine and Pyraloxime Methylchloride for patient with AOPP , Penehyclidine Hydrochloride combining Atropine and Pyraloxime Methylchloride has better effect, shorter course and lower fatality rate.%目的：探讨长托宁联合阿托品、氯磷定抢救急性有机磷农药中毒（AOPP）患者的效果。方法：将2006年1月-2012年12月收治的AOPP患者118例随机分为对照组和观察组各59例，分别应用阿托品＋氯磷定治疗和长托宁＋和阿托品＋氯磷定治疗，比较两组患者的胆碱酯酶（ChE）恢复时间、住院时间和病死率。结果：治疗组ChE恢复时间、住院时间和病死率均显著低于对照组（P ＜0．05）。结论：长托宁联合阿托品、氯磷定治疗AOPP的疗效较阿托品、氯磷定好，且疗程短、病死率低。
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