以海藻酸钠-羧甲基壳聚糖(ALG--CMC)为载体材料,甘草次酸(β)(GA)为模型药物,采用滴制法制备了ALG-CMC负载GA的复合凝胶珠.采用体视显微镜与扫描电镜(SEM)观察了凝胶珠的外观形貌,考察了凝胶珠的溶胀性能和体外释药行为,以及CaCl2浓度对凝胶珠的包封率和载药量的影响.结果表明,湿态凝胶珠形态规整、粒径分布均匀,平均粒径约2900μm,包封率最高达85.7％,载药量为18.0％；CaCl2浓度对包封率和载药量几乎无影响；在pH=1.2的HCl溶液中凝胶珠溶胀率小、累积释放率低；在pH=7.4的磷酸盐缓冲(PBS)溶液中凝胶珠溶胀率大、累积释放率高.滴制法制备ALG-CMC凝胶珠条件温和、不接触有机溶剂,凝胶珠具有pH敏感性且能有效载药.该体系有可能成为GA的给药载体材料.%Alginate-Carboxymethyl chitosan (ALG-CMC) was used as a carrier to formulate GA loaded ALG-CMC gel beads via dropping method with 18β-glycyrrhetinic acid(GA) as model drug. The morphologies of the beads were observed with stereomicroscope and scanning electron microscope, in vitro swelling characteristics, in-vitro drug release, the effect of CaCl2 concentration on the drug entrapment efficiency and loading amount of the beads were also investigated. The results show that the wet beads have narrow size distribution, regular spherical morphology, mean size of 2900μm, drug encapsulation efficiency up to 85.7%, and drug loading amount up to 18.0%; CaCl2 concentration has no significant effect on the drug entrapment efficiency and loading amount of the beads; In pH=7.4 PBS solution, the swelling rate and the accumulated drug release rate of the beads are significantly higher than those in pH= 1.2 hydrochloric acid solution. The dropping method provides mild preparation condition without using organic solvent, the prepared beads have pH sensitivity and can efficiently deliver drug. The alginate-carboxymethyl chitosan beads are promising for drug carrier material.
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