目的 探讨介入治疗中晚期非小细胞肺癌(NSCLC)的患者的中性粒细胞/淋巴细胞比值(NLR)与其预后的相关性.方法 回顾性分析我院介入科2014年1月1日～2017年1月1日收治的68例行介入治疗的中晚期非小细胞肺癌患者的临床资料.计算术前NLR值,并通过建立ROC生存曲线分为高NLR组(NLR≥3.8)和低NLR组(NLR＜3.8),比较两组的无进展生存时间及总生存时间,同时对可能影响患者预后的危险因素行单因素及多因素分析.结果 所有患者在接受介入治疗后,中位总生存时间为421 d;其中高NLR组中位总生存时间为292 d,低NLR组中位总生存时间为506 d,差异有统计学意义(P＜0.05);同时高NLR组中位无进展生存时间为152 d,低NLR组中位无进展生存时间为341 d,差异有统计学意义(P＜0.05).在单因素分析中,存在远处转移、介入手术次数＜3次及NLR≥3.8均是影响总生存时间和无进展生存时间的危险因素(P＜0.05);在多因素分析中,存在远处转移、NLR≥3.8是影响总生存时间的独立危险因素(P＜0.05);存在远处转移、介入手术次数＜3次及NLR≥3.8是影响无进展生存时间的独立危险因素(P＜0.05).结论 术前NLR可作为介入治疗中晚期NSCLC患者的预后指标,NLR 高者预后差.%Objective To investigate the correlation between neutrophil/lymphocyte ratio (NLR) and prognosis in patients with advanced non-small cell lung cancer (NSCLC). Methods The clinical data of 68 patients with advanced non-small cell lung cancer who underwent interventional therapy from January 1, 2014 to January 1, 2017 were retrospectively analyzed. The preoperative NLR values were calculated and divided into high NLR group (NLR≥3.8) and low NLR group (NLR＜3.8) by establishing ROC survival curve. The progression-free survival time and total survival time of the two groups were compared, and the patients may be affected. The prognostic risk factors were analyzed by single factor and multivariate factors. Results The median overall survival was 421 d in all patients after interventional therapy. The median overall survival was 292 d in the high NLR group and 506 d in the low NLR group,the difference was statistically significant(P＜0.05); at the same time, the median progression-free survival time was 152 d in the high NLR group and 341 d in the low NLR group, the difference was statistically significant(P＜0.05). In the univariate analysis, the presence of distant metastasis, the number of interventional procedures ＜3 times and NLR ≥ 3.8 were risk factors affecting the overall survival time and progression-free survival time (P＜0.05); in the multivariate analysis, there was a distant place. Metastasis and NLR≥3.8 were independent risk factors for the overall survival time (P ＜0.05). The presence of distant metastasis, the number of interventional procedures ＜3 times and NLR≥3.8 were independent risk factors for progression-free survival (P＜0.05).Conclusion Preoperative NLR can be used as a prognostic indicator for patients with advanced NSCLC. The prognosis of NLR is poor.
展开▼
