目的：观察和评估阿托伐他汀联合阿仑膦酸钠治疗高龄骨质疏松的疗效及其对OPG和骨代谢指标的影响。方法：随机选取本院2012年2月-2015年3月收治的高龄骨质疏松患者100例，按照治疗方式的不同分为观察组和对照组，各50例，对照组给予阿仑膦酸钠口服治疗，观察组在对照组的基础上加服阿托伐他汀治疗，疗程均为0.5年。对比分析两组患者的临床疗效、不同部位的骨密度、骨保护素（OPG）、骨代谢指标（骨碱性磷酸酶BAP、N-端骨钙素N-MID、骨钙素OC）水平、VAS评分。结果：观察组患者的总有效率为96.00%，明显高于对照组患者的78.00%，差异有统计学意义（P<0.01）；两组患者治疗后不同部位的骨密度均明显高于治疗前，且观察组治疗后不同部位的骨密度均明显高于对照组，差异均有统计学意义（P<0.01）；两组患者治疗后OPG水平均明显高于治疗前，且观察组治疗后的OPG水平明显高于对照组患者，差异均有统计学意义（P<0.05）；两组患者治疗后的BAP、N-MID、OC水平明显高于对照组患者，且观察组治疗后BAP、N-MID明显高于对照组患者（P<0.05），观察组治疗后OC水平明显高于对照组患者，差异有统计学意义（P<0.01）；两组患者治疗后VAS评分明显低于治疗前，且观察组患者治疗后的VAS评分明显低于对照组，差异均有统计学意义（P<0.01）。结论：阿托伐他汀联合阿仑膦酸钠治疗高龄骨质疏松的疗效显著，能有效提高患者的OPG水平，改善骨代谢，增加骨密度，减轻患者的疼痛程度。%Objective:To observe and evaluate the efficacy of Atorvastatin combined with Alendronate in the treatment of osteoporosis in elderly patients and its effect on OPG and bone metabolism index.Method:A total of 100 patients benign osteoporosis in our hospital from February 2012 to March 2015 were randomly selected and they were divided into the observation group(50 patients were treated with Atorvastatin on the basis of the control group) and the control group (50 patients were simply treated with Alendronate).The course of treatment was half a year.Comparative analysis of the clinical efficacy,different parts of the bone mineral density and OPG and bone metabolic markers(BAP,N-MID,OC),VAS score of two groups.Result:The total effective rate of the observation group was 96.00%,which was significantly higher than that of control group(78.00%),and the difference was statistically significant(P<0.01).Two groups of patients with different parts of bone density were significantly higher than before treatment,and the observation group after treatment of different parts of the bone density were significantly higher than those of the control group,the differences were statistically significant (P<0.01).Two groups of patients after treatment of OPG levels were significantly higher than before treatment, and the observation group after treatment OPG levels were significantly higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the patients in two groups of BAP and N-MID, OC levels were significantly higher than those of patients in the control group and BAP,N-MID levels of the observation group after the treatment were significantly higher than those of the control group (P<0.05),OC levels of the observation group after the treatment was significantly higher than that of the control group,the difference was statistical significance(P<0.01).After treatment,VAS score of two groups was significantly lower than before treatment,and the VAS score of the observation group after treatment was significantly lower than that of the control group,the difference was statistically significant (P<0.01).Conclusion:Atorvastatin combined with Alendronate in the treatment of osteoporosis in elderly patients with significant effect,can effectively improve the OPG level of patients and bone metabolism,increase bone density,relieve the pain of patients.
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