Objective:To observe the application effect of trane in the treatment of patients with recurrent persistent HPV infection and influence situation of cervical local immune.Method:84 patients with recurrent persistent HPV infection in our hospital from February 2015 to April 2016 were selected as the study objects,they were divided into two groups according to the method of random number table,42 cases in each group.The control group was treated with foscarnet sodium,observation group was treated with trane,then the total effective rates,vaginal douche Th1 and Th2 related indexes before and after the treatment of two groups were compared.Result:The total effective rates of observation group with different disease were all higher than those of control group,the expression levels of vaginal douche Th1 and Th2 related indexes at different time after the treatment were all better than those of control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of trane in the treatment of patients with recurrent persistent HPV infection is better,and its influence for the cervical local immune is more active,so its application value in the patients with recurrent persistent HPV infection is higher.%目的：观察派特灵在复发性持续性HPV感染患者中的应用效果及对宫颈局部免疫的影响情况。方法：选取2015年2月-2016年4月期间于本院进行治疗的84例复发性持续性HPV感染患者为研究对象，所有患者按照随机数字表法分为两组，每组各42例。对照组以膦甲酸钠进行治疗，观察组则以派特灵进行治疗，将两组患者的治疗总有效率及治疗前后的阴道灌洗液Th1、Th2相关指标表达水平进行比较。结果：观察组患者的治疗总有效率高于对照组，治疗后不同时间段的阴道灌洗液Th1、Th2相关指标表达水平均好于对照组，两组比较差异均有统计学意义（P<0.05）。结论：派特灵在复发性持续性HPV感染患者中的应用效果相对更好，且对宫颈局部免疫的影响更为积极，因此认为其在复发性持续性HPV感染患者中的应用价值更高。
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