Objective:To observe the clinical effect of Compound Danshen Dropping Pill in the treatment of early diabetic nephropathy.Method:A total of 74 type 2 diabetes mellitus(T2DM) patients with diabetic nephropathy (DN) who met the criteria for DN from January 2012 to January 2013,were retrospectively analyzed and randomized into the treatment group(n=53) and the control group(n=21).All patients received rational hypoglycemic, step-antihypertensive,lipids-adjusting treatment and the treatment group received Compound Danshen Dropping Pill(15 pills,tid),add itionally.Laboratory indexes such as blood glucose,HbA1c,and urine trace albumin/creatinine were examined 24 weeks after treatment.Result:The levels of urine trace albumin/creatinine of two groups were decreased after versus before treatment(P<0.05),but the decreases of urine trace albumin/creatinine had not significant differences between two groups(P>0.05).Conclusion:The comprehend-sive treatment combined with Compound Danshen Dropping Pill for 24 weeks can effectively reduce urine trace albumin/createnine.%目的：观察复方丹参滴丸治疗早期糖尿病肾病的效果。方法：采用多中心、前瞻性、随机分组，开放、平行及前后对照的观察性研究，选取2012年1月-2013年1月在丹东各级医院就诊的2型糖尿病合并早期肾病的患者，共74例，随机分为治疗组（n=53）和对照组（n=21）。在合理降糖、降压和降脂等综合治疗基础上，治疗组加用复方丹参滴丸，15粒/次，3次/d；对照组保持原治疗方案不变，观察期共24周。观察治疗前后两组患者血糖、HbA1c及尿微量白蛋白/尿肌酐的变化。结果：治疗后两组患者尿微量白蛋白/尿肌酐均较治疗前明显下降，差异均有统计学意义（P<0.05），治疗组患者尿微量白蛋白/尿肌酐较对照组呈明显下降趋势，但两组比较差异无统计学意义（P>0.05）。结论：在原治疗方案不变的情况下，复方丹参滴丸在短期内（24周）可使早期糖尿病肾病的尿微量白蛋白/尿肌酐呈下降趋势。
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