钙离子在细胞生存进程中起着至关重要的作用，例如细胞内信号传导，蛋白质折叠，酶的活化和程序性细胞死亡的启动。基质交感分子1（STIM1）是细胞内质网膜上的跨膜蛋白，其作为细胞内质网的钙离子传感器，可与胞膜下的Orai1蛋白结合，参与细胞内外钙浓度的调节。钙离子失调已被证实与多种心血管疾病有关，本文通过对STIM1在与心血管相关疾病中的作用进行回顾。%Calcium plays a vital role in cell survival process,such as intracellular signaling,protein folding, enzyme activation and start programmed cell death. Stromal interaction molecule 1(STIM1)transmembrane protein within the cells of the endoplasmic reticulum,as endoplasmic reticulum calcium ion sensor can be combined with membrane proteins under Orai1 involved in the regulation of intracellular calcium concentration.Calcium imbalance has been linked to a variety of cardiovascular diseases,this paper were reviewed by STIM1 in cardiovascular-related diseases.
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