Objective:To discuss and investigate the implementation of investigation of mixed infection of atypical pathogenic bacteria in patients with COPD ,and the significance of actively implement the treatment and efficacy evaluation.Method:200 patients with COPD in our hospital from July 2012 to April 2014 were selected,they were randomly divided into the control group and the treatment group,100 cases in each group.The control group was given conventional treatment.On the basis of conventional treatment,the treatment group was given routine examination of atypical pathogens mixed infection and the etiological examination results were analyzed in detail.Result:Before anti infection scheme adjustment,the treatment effect of treatment group was significantly better than the control group (P<0.05).After anti infection scheme adjustment,there were no statistically significant differences in the treatment effect and mortality between the two groups(P>0.05),and the treatment effect of control group was significantly better than before the adjustment(P<0.05).Conclusion:Carrying out the investigation of mixed infection of atypical pathogenic bacteria in patients with COPD,can improve the treatment effect of the patients.%目的：研究与探讨在COPD患者中开展非典型致病菌混合感染的调查，积极实施治疗并作疗效评估的意义。方法：选用2012年7月-2014年4月入住本院治疗的COPD患者200例，随机分成两组。给予对照组患者常规治疗，治疗组患者在常规治疗的基础上，进行常规非典型致病菌混合感染的检查，并详细分析病原学检查结果。结果：调整抗感染方案前，治疗组治疗效果优于对照组（P<0.05），调整抗感染方案后，对照组治疗效果、死亡率与治疗组比较差异无统计学意义（P>0.05），调整抗感染方案后对照组治疗效果明显好于调整前（P<0.05）。结论：在COPD患者中开展非典型致病菌混合感染的调查，可以提升患者的治疗效果。
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