Objective:To explore the fat in a role in the treatment of children with neonatal hypoxic ischemia encephalopathy.Method:120 children with HIE were selected as the research object, the patients were randomly divided into two groups, the experimental group of patients on the basis of routine therapy used ganglioside treatment, control group children take regular treatment.The curative effect of patients after treatment, clinical symptoms returned to normal time and so on were investigated.Result:After treatment,the effect was obviously improved, the recovery time of clinical symptom was shorten, and DQ scores was improved, serum NSE levels was lower too of the experimental group, compared with the control group differences were statistically significant (P<0.05).Conclusion:The ganglioside in the treatment of neonatal hypoxic ischemia encephalopathy has obvious clinical effect, can improve the effect of clinical treatment, is worth further promotion and use.%目的：探究经节苷脂在新生儿缺血缺氧性脑病（HIE）患儿治疗中的作用。方法：选取2013年6月-2014年6月在本院住院治疗的120例HIE患儿作为研究对象，随机数字表法均分为试验组和对照组，对照组患儿采取常规治疗，试验组在常规治疗的基础上采用神经节苷脂进行治疗。观察两组治疗后的疗效、临床症状恢复正常的时间等指标。结果：试验组治疗后的总有效率明显提高，临床症状恢复时间缩短，DQ得分提高，血浆NSE水平降低，与对照组比较差异均有统计学意义（P<0.05）。结论：神经节苷脂在治疗新生儿缺血缺氧性脑病上具有明显的临床效果，能提高临床治疗效果，值得进一步推广和使用。
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