Diabetes is characterized by chronic hyperglycemia metabolic diseases. with the improvement of people's living standards, the aging population, the incidence rate was gradually rising trend. Diabetes pathogenesis is still not very clear so far, and pathogenesis of diabetes is now a hot topic. Interleukin-4 (IL-4) (10kb) located on chromosome 5q31.1, there are four polymorphic alleles. which has a strong linkage disequilibrium. In this paper, the correlation progress (IL-4) gene polymorphisms of interleukin-4 with type 1 diabetes, type 2 diabetes, diabetes complications start on.%糖尿病是慢性高血糖为特征的代谢性疾病。随着人民生活水平的提高、人口老化，发病率呈逐渐升高的流行趋势。糖尿病发病机制到目前仍不十分明确，糖尿病发病机制是现在的热点话题。白细胞介素-4（IL-4）（10 kb）位于染色体5q31.1上，有4个多态性的等位基因，它们具有很强的连锁不平衡。本文就白细胞介素-4（IL-4）基因多态性与1型糖尿病、2型糖尿病、糖尿病并发症的相关性进展展开论述。
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