目的：探究皮肤CD30阳性淋巴组织增生性疾病的临床病理特点。方法：选取2008年2月-2009年8月本院收治的5例皮肤CD30阳性淋巴组织增生性疾病患者，包括2例淋巴瘤样丘疹病和3例原发性皮肤CD30+间变性大细胞淋巴瘤，收集其临床治疗及随访资料，并进行回顾性分析，着重比较各型CD30阳性淋巴组织增生性疾病的病理及临床特点。结果：2例淋巴瘤样丘疹病的发病年龄分别是28岁和62岁，临床特点为反复发作的结节性皮肤样丘疹，随访生存率为100%；3例原发性皮肤CD30+间变性大细胞淋巴瘤患者发病年龄分别为7岁、54岁、70岁，临床特点为结节肿块伴有溃疡形成，随访生存率81.0%。结论：CD30阳性淋巴组织增生性疾病的临床表现多样，不同疾病及分型的病理表现、临床治疗、预后均不同，在临床确诊时需做好鉴别诊断，明确疾病分型，以进行有针对性的治疗。%Objective:To investigate the clinic pathologic features of primary cutaneous CD30+lymphoproliferative disease.Method:A total of 5 patients that had primary cutaneous CD30+lymphoproliferative disease including 3 cases of CALCL and 2 cases of LyP from February 2008 to August 2009 in our hospital were selected as the research objects.Clinical treatment and follow-up data were summarized and clinic pathologic features was emphasized. Result:Among 5 cases,2 cases were lymphomatoid papulosis(LyP),the age of onset of 2 cases of lymphomatoid papulosis was respectively 28 and 62 years old and presented multiple recurrent,self-healing skin papules,the survival rate was 100%.Among 5 cases,3 cases were primary cutaneous anaplastic large-cell lymphomas(C-ALCL),7,54,70 years old respectively and presented nodules,masses and plaques,sometimes with ulceration,and the survival rate was 100%.Conclusion:The clinical manifestations of CD30+lymphoproliferative disease are various different diseases,pathological presentation of different diseases and parting,clinical treatment and prognosis are different.It needs to make the differential diagnosis and explicit the classification of disease in clinical diagnosis for targeted treatment.
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