Objective:To study the muscular layer in invasive bladder cancer treatment,the clinical effect of transurethral secondary cutting treatment.Method:50 patients after transurethral plasmakentic vaporization of electricity cut for the first time were selected,and they were muscularis invasive bladder cancer by pathological diagnosis,all patients underwent secondary electricity cut method ofter 4-6 weeks,the cancer histopathological characteristics after the primary surgery and the second postoperative were compared.Result:After treatment for secondary,in 50 patients,21 cases of tumor survival,20 cases found tumor residual lesions,6 cases found tumor missed lesions,5 patients already exists residual lesions and missed lesions. After treatment from the pathological staging,21 cases of tumor survival,10 cases of Ta,11 cases of T1 phase,8 cases progressed to T2 stage. Through the clinical analyzed,single factor and multiple factors that T1 phase,high grade and tumor diameter>3 cm were secondary electric cut operation pathological staging to T2 stage independent risk factors.Conclusion:Transurethral secondary cutting treatment,which can effectively improve the patient’s quality of life,the T1 phase,high grade and tumor>3 cm in diameter is independent risk factors in the development of disease,clinical should take seriously.%目的：探讨非肌层浸润性膀胱肿瘤治疗中，经尿道二次电切治疗的临床效果。方法：选取本院50例初次行经尿道电切之后，病理诊断为非肌层浸润性膀胱癌患者，全部患者于术后4~6周行二次电切术，比较初次手术与二次术后的肿瘤组织病理学特点。结果：经二次治疗后，50例患者中，21例无肿瘤生存，20例发现肿瘤残余病灶，6例发现肿瘤遗漏病灶，5例既存在残留病灶又存在遗漏病灶。治疗后从病理分期看，21例无肿瘤生存，10例为Ta期，11例为T1期，8例进展至T2期。经临床单因素及多因素分析得出：T1期、高分级及肿瘤直径>3 cm均是二次电切术病理分期升至T2期的独立危险因素。结论：经尿道二次电切治疗，可有效改善患者的生存质量，T1期、高分级及肿瘤直径>3 cm是患者疾病发展的独立危险因素，临床应充分重视。
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