Objective:To explore the effect of Magnesium sulfate in treatment of children with asthmatic diseases.Method:100 children with pediatric asthmatic diseases in our hospital were selected from December 2011 to March 2013.They were divided into the treatment group and the control group according to different order of admission,50 cases in each group.Two groups were given comprehensive treatment.The treatment group on the basis of conventional treatment was combined with 25%magnesium sulfate,0.1-0.2 mL/(kg·d),adding 5%glucose diluted to 1%-1.4%concentration of liquid intravenous drip,drip off 1 hour,once per day,3 days for one period of treatment,the patient’s clinical presentation at any time were observed, symptoms and signs of easing of the two groups were analyzed.Result:The treatment group in cough,wheezing,pulmonary symptoms disappeared time and hospitalization time compared with the control group were significantly reduced,cost of hospitalization was significantly lower than the control group,and the total efficiency of 96.0%in treatment group was significantly higher than that in control group(86.0%),the differences were statistically significant(P<0.05).Conclusion:Comprehensive treatment combined with magnesium sulfate is beneficial for patient with asthmatic disease,and it has the advantages of good curative effect,quick,safe and non-toxic side effect,is worth the clinical promotion.%目的：探讨硫酸镁治疗小儿喘息性疾病的疗效。方法：选取本院儿科2011年12月-2013年3月收治的100例患小儿喘息性疾病的患儿，根据入院顺序不同分为治疗组和对照组各50例。两组患儿均给予综合治疗。治疗组在传统治疗基础上加用25%硫酸镁0.1~0.2 mL/（kg·d），加入5%葡萄糖稀释成1%~1.4%浓度的液体静脉滴入，1 h滴完，1次/d，3 d为一疗程，随时观察两组患儿的临床表现，分析其症状、体征的缓解情况。结果：治疗组患儿的咳嗽、喘息、肺部体征消失时间及住院时间与对照组比较均明显缩短，住院费用明显低于对照组，且治疗组总有效率96.0%明显高于对照组的86.0%，比较差异均有统计学意义（P<0.05）。结论：在常规治疗基础上加用硫酸镁治疗小儿喘息性疾病具有显效快，疗效好，安全无毒副作用等优点，值得临床推广。
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