Objective:To explore the clinical value of bronchoscope-guided cryotherapy combined with chemotherapy and radiotherapy to treat patients with advanced NSCLC lung cancer.Method:50 patients with advanced lung cancer were randomized assigned to two groups, each group had 50 cases. The treatment group received bronchoscope-guided cryotherapy and chemotherapy and radiotherapy; the control group received cryotherapy and chemotherapy. The treatment effect, patient quality of life, the median survival and 1 year survival rate of the two groups were observed.Result:The response rate in the treatment group and the control groups were 73.2% and 55.8% respectively (P<0.05). Patients quality of life of the two groups were improved, cough, hemoptysis, intermittent dyspnea symptoms were improved, KPS scores were increased, there were no statistical significance (P>0.05). The median survival time was 15.2 months and 10.3 months, the one-year survival rate was 76.3% and 56.3%, there was different in two groups (P<0.05).Conclusion:Bronchoscope-guided cryotherapy combine with chemotherapy and radiotherapy can treat NSCLC, relieve cough, hemoptysis, fever, the symptom such as difficulty in breathing, and improve the quality of life and extended survival period.%目的：观察电子支气管镜冷冻治疗联合放化疗治疗中晚期中央型非小细胞肺癌（NSCLC）的临床疗效。方法：选择经病理确诊的无手术征或拒绝手术或不能耐受手术的中晚期中央型NSCLC患者100例，按随机数字表法分为治疗组及观察组各50例，治疗组采用电子支气管镜冷冻+放疗+全身化疗；对照组采用电子支气管镜冷冻+全身化疗。观察两组治疗有效率、患者生活质量、中位生存期及1年生存率。结果：治疗组可评价41例，有效30例（73.2%），对照组可评价43例，有效24例（55.8%），两组比较差异有统计学意义（P<0.05）；两组患者生存质量改善相仿，咳嗽、间断性咯血、呼吸困难症状明显改善，KPS评分均有提高，两组比较差异无均统计学意义（P>0.05）；中位生存期治疗组为15.2个月，对照组10.3个月，1年生存率分别为76.3%和56.3%，两组比较差异有统计学意义（P<0.05）。结论：电子支气管镜介导冷冻治疗联合放化疗可以有效治疗中晚期NSCLC，缓解咳嗽、咯血，发热，呼吸困难等症状，提高患者的生活质量及生存期。
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