目的：：探讨急性冠脉综合征( ACS)患者血压昼夜节律变化与肿瘤坏死因子α( TNF-α)、高敏C反应蛋白( hs-CRP)水平的关系。方法：86例ACS患者,根据24 h动态血压(24hABPM)昼夜节律监测结果分为杓型组(39例)和非杓型组(47例)。固相夹心酶联免疫法测定血浆分别检测两组患者的TNF-a和hs-CRP水平。结果：非杓型组患者的TNF-α和hs-CRP水平显著高于杓型组(P均<0.05)。非杓型组患者夜间收缩压(nSBP)与TNF-α、hs-CRP水平正相关(r=0.512、0.465,P均<0.01)。结论：ACS患者的血压非杓型节律改变与其炎性状态关系密切。%Objective:To explore correlations of different blood pressure circadian rhythm and plasma levels of tumor necrosis factor alpha (TNF-α) and high-sensitivity c-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS). Meth-ods:86 patients with ACS who accepted 24 hours ambulatory blood pressure (24hABPM) monitoring were divided into dipper group (39 cases) and non-dipper group (47 cases) according to blood pressure circadian rhythm. The plasma levels of TNF-αand hs-CRP were determined at admission using ELISA. Results:The plasma levels of TNF-αand hs-CRP in non-dipper group were significantly higher than those in dipper group respectively (P<0. 05). There were positive correlations between night systolic blood pressure (nSBP) and TNF-α, hs-CRP levels of non-dipper group, respectively (r=0. 512, 0. 465, both P<0. 001). Conclusions:There is a close relationship between non-dipper blood pressure rhythm and inflammatory state in the patients with ACS.
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