Objective [Abstract] Objective To observe the anti-inflammatory and osteogenesis of the complex particles composed of ceric oxide and bioglase implanted into rabbit femoral defects. Methods The bilateral penetrating femoral condylar defects of 6mm in diameter were made in 6 adult New Zealand White rabbits, bioglass particles and complex particles composed of ceric oxide and bioglass were randomly implanted into the left or right condylar defect. Animals were sacrificed at 2 and 4 weeks after operation (3 each),specimens from defect sites were harvested for histological examination to observe the inflammatory reaction and calculate the ratio of new bone and grafts on the defect area. Results No inflammatory reaction was found in the defect area filled with bioglass particles or complex particles composed of ceric oxide and bioglass. New bone was observed in the defects 2 weeks after operation, and no significant difference on the bone formation rate existed between the two materials (P＞0. 05). The osteogenesis of both materials was more obvious in the 4th week than in the 2nd week (P＜0.05 or 0.01), but the formation rate was similar by the two materials (P＞0.05). No obvious degradation of the grafts implanted into the defect area occurred in the 4th week compared with that in the 2nd week (P＞0. 05).Conclusion The complex particles composed of ceric oxide and bioglass has anti-inflammatory activity and similar osteogeneais to normal bioglass particles, and may be used in the repair of bone defects.%目的 观察二氧化铈复合生物玻璃颗粒植入兔股骨缺损后的抗炎及成骨能力.方法 成年新西兰大白兔6只,双侧股骨髁部制造直径6mm的贯穿型缺损,然后在左右髁部随机植入生物玻璃颗粒或二氧化铈复合生物玻璃颗粒,于术后第2周和第4周处死动物(各3只),对缺损部位行组织学观察,了解有无炎性反应并计算新生骨及材料占缺损的百分比.结果 两种材料缺损处均未观察到炎性反应.2周时缺损部位即可观察到新生骨形成,且两种材料新骨生成率无显著差异(P>0.05);4周时两种材料植入处的新生骨量均较2周时明显增加(P<0.05或P＜0.01),但两种材料新骨生成率比较显著学差异(P>0.05),且与2周时比较材料均未见明显降解(P>0.05).结论 二氧化铈复合生物玻璃颗粒具有抗炎能力,且成骨能力与普通生物玻璃颗粒类似,有望用于骨缺损的修复.
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