Objective To analyze the diagnostic value of serum βhuman chorionic gonadotropin (β-HCG) and progesterone combined with transvaginal ultrasonography in early tubal pregnancy.Methods Total of 120 cases of suspected early tubal pregnancy were selected in Benxi Central Hospital from Jan . 2013-Jan.2014 were included in the study.Serum β-HCG and progesterone were measured,and transvaginal ultrasound was done,and the clinical test results were compared and analyzed.Results There were 50 cases of early tubal pregnancy,70 cases of intrauterine pregnancy.The endometrial thickness,serum β-HCG,pro-gesterone value of early tubal pregnancy cases were significantly less than the intrauterine pregnancy cases [(6.7 ±1.5) mm vs (10.9 ±1.4) mm,(787 ±110)U/L vs (5638 ±193) U/L,(9.0 ±2.6) mg/L vs (24.6 ±4.7) mg/L],the differences were statistically significant(P<0.01);the serumβ-HCG level at the first day and after 48 hours of early tubal pregnancy cases were lower than the intrauterine pregnancy cases [(787 ±110) U/L vs (5638 ±193) U/L,(769 ±113) U/L vs (11 087 ±1827) U/L] (P<0.01),the serum β-HCG level 48 hours laterand on the first day of the early tubal pregnancy cases had no significant difference(P>0.05),while the serum β-HCG levels 48 hours later of the intrauterine pregnancy cases was significantly higher than the treatment day[(5638 ±193) IU/L vs (11 087 ±1827) U/L](P <0.05);diagnostic accuracy rate of serum β-HCG was 59.2%,of progesterone alone was 56.7%,of vaginal ultra-sound diagnosis was 67.5%,of the three combined diagnosis was 88.3%.Conclusion In the early tubal pregnancy clinical diagnosis,serumβ-hCG,progesterone determination combined with transvaginal ultrasound has high value ( there is no significant difference from the Gold standard ) , which is helpful to reduce the missed diagnosis rate and misdiagnosis rate,providing scientific reference for the clinical diagnosis,treatment and prognosis,thus has an important guiding significance.%目的：分析和探讨血清β人绒毛膜促性腺激素（β－HCG）、孕酮测定结合阴道超声在早期输卵管妊娠中的诊断价值。方法选取2013年1月至2014年1月本溪市中心医院收治的疑似早期输卵管妊娠患者120例，测定血清β－HCG、孕酮水平，并采用阴道超声进行检查，对患者临床检查结果进行比较和分析。结果早期输卵管妊娠患者50例，宫内早孕孕妇70例。早期输卵管妊娠患者子宫内膜厚度、血清β－HCG、孕酮值显著低于宫内妊娠孕妇[（6．7±1．5） mm 比（10．9±1．4） mm，（787±110） U／L 比（5638±193） U／L，（9．0±2．6） mg／L比（24．6±4．7） mg／L]，差异有统计学意义（P＜0．01）；早期输卵管妊娠患者血清β－HCG 水平在就诊当日与48 h 内均低于宫内妊娠孕妇[（787±110） U／L比（5638±193） U／L，（769±113） U／L比（11087±1827） U／L]（P＜0．01），早期输卵管妊娠患者48 h后血清β－HCG水平与就诊当日差异无统计学意义（ P＞0．05），而宫内妊娠孕妇48 h后血清β－HCG 水平明显高于就诊当日[（5638±193） U／L 比（11087±1827） U／L]（P ＜0．05）；血清β－HCG单独诊断准确度为59．2％，孕酮单独诊断准确度为56．7％，阴道超声诊断准确度为67．5％，三者联合诊断准确度为88．3％。结论在早期输卵管妊娠临床诊断中，血清β－HCG、孕酮测定结合阴道超声具有较高的诊断价值（其与金标准尽在准确率之间无明显差异）有利于降低早期输卵管妊娠漏诊率与误诊率，为临床疾病的诊断、治疗及预后提供科学的参考依据，具有重要的指导意义。
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