Objective To study effect of of Shuxuetong combined with Oxagrel on hemorheology and clinical symptoms for transient ischemic attack ( TIA) .Methods Total of 94 patients with TIA admitted to Wuhan University People′s Hospital from Jun.2012 to Dec.2013 were included in the study and divided into observation group and control group according to random number table method,47 cases each.Ozagrel treat-ment was given to the control group(ozagrel 40-80 mg added 250 mL of 5% glucose solution,2 times a day, 24 h of continuous intravenous infusion);the observation group was given ozagrel combined with Shuxuetong treatment(6 mL of Shuxuetong injection added to 5% glucose injection or 0.9% sodium chloride injection) , once per day,slow intravenous infusion,and ozagrel administration was same as the control group.Blood rhe-ology.Both groups were treated for 2 weeks continuously.The hemorhelogy changes, neurologic functional defect,daily life ability and the therapeutic effect of the two groups were compared .Results Total efficacy of the observation group was significantly higher than the control group[ 93.6%(44/47) vs 76.6%(36/47), P<0.05].After treatment,the high shear whole blood viscosity,low shear whole blood viscosity,plasma vis-cosity and fibrinogen of the observation group were significantly lower than the control group [ ( 4.12 ± 0.21) mPa· s vs (4.52 ±0.29) mPa· s,(5.45 ±0.29) mPa· s vs (7.32 ±1.31) mPa· s,(1.19 ± 0.15) mPa· s vs (1.61 ±0.35) mPa· s,(2.17 ±0.11) g/L vs (3.19 ±0.29) g/L,P <0.01].After treatment,nerve function defect score of the observation group was significantly lower than the control group [(13.8 ±2.3) scores vs (18.6 ±3.1) scores],Barthel index was significantly higher than the control group(78 ±8 vs 61 ±6),the difference was statistically significant(P <0.01).Conclusion Shuxuetong combined with oxagrel help to improve the hemorheology,lower cranial nerve function defect,and improve the therapeutic effect.%目的：探讨奥扎格雷联合疏血通对短暂性脑缺血发作（ TIA）患者血液流变学及临床症状的影响。方法选择2012年6月至2013年12月武汉大学人民医院收治的94例TIA患者为研究对象，采用随机数字表法分为观察组和对照组，各47例。对照组给予奥扎格雷治疗，奥扎格雷40～80 mg加入5％葡萄糖溶液250 mL中，每日2次，24 h连续静脉滴注；观察组采用奥扎格雷联合疏血通治疗，疏血通注射液6 mL加于5％葡萄糖注射液（或0.9％氯化钠注射液）250 mL中，每日1次，缓慢静脉滴注，奥扎格雷治疗方法同对照组。两组均连续治疗2周。观察两组患者的血液流变学变化、神经功能缺损、日常生活能力及治疗效果。结果观察组总有效率显著高于对照组[93.6％％（44／47）比76.6％（36／47）]，差异有统计学意义（P ＜0.05）。治疗后观察组高切全血黏度、低切全血黏度、血浆黏度及纤维蛋白原均明显低于对照组[（4.12±0.21） mPa· s 比（4.52±0.29）mPa· s，（5.45±0.29）mPa· s 比（7.32±1.31）mPa· s，（1.19±0.15）mPa· s 比（1.61±0.35）mPa· s，（2.17±0.11）g／L比（3.19±0.29） g／L]，差异均有统计学意义（P＜0.01）。治疗后观察组神经功能缺损评分明显低于对照组[（13.8±2.3）分比（18.6±3.1）分]，Barthel指数明显高于对照组（78±8比61±6），差异有统计学意义（P＜0.01）。结论奥扎格雷联合疏血通有利于改善患者血液流变学，降低脑神经功能缺损，提高治疗效果。
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