目的：分析并探讨不同阶段糖尿病肾病患者血清高敏 C 反应蛋白、C 反应蛋白水平的变化特点。方法选取2005年3月至2015年4月在广西壮族自治区职业病防治研究院接受治疗的2型糖尿病患者100例，根据尿蛋白／尿肌酐结果将100例患者分为单纯型糖尿病组（＜30 mg／g，n＝28）和糖尿病肾病组（≥30 mg／g，n＝72），选取同期健康体检患者30例为健康对照组。使用免疫荧光法检测高敏C反应蛋白和C反应蛋白水平。结果单纯性糖尿病组高敏C反应蛋白水平为（1.53±0.47） mg／L，C反应蛋白水平为（7.23±1.13） mg／L。糖尿病肾病组高敏C反应蛋白水平为（2.14±0.63） mg／L，C反应蛋白水平为（19.35±4.12） mg／L。健康对照组高敏C反应蛋白水平为（0.71±0.21） mg／L，C反应蛋白水平为（1.91±0.34） mg／L。糖尿病肾病组高敏 C反应蛋白和 C反应蛋白水平显著高于单纯型糖尿病组、健康对照组，差异有统计学意义（ P＜0.05）。随着蛋白尿水平的提高，血清高敏C反应蛋白水平和C反应蛋白水平也逐渐升高（ P＜0.05）。小量蛋白尿组高敏C反应蛋白为（1.70±0.31） mg／L，C反应蛋白为（12.53±1.24） mg／L。中量蛋白尿组高敏 C 反应蛋白为（2.39±0.32） mg／L，C反应蛋白为（22.36±3.11） mg／L。大量蛋白尿组高敏C反应蛋白为（2.91±0.47） mg／L，C反应蛋白为（32.93±4.35） mg／L。大量蛋白尿组血清高敏C反应蛋白水平和C反应蛋白水平高于小量蛋白尿组、中量蛋白尿组（P＜0.05）；中量蛋白尿组显著高于小量蛋白尿组（P＜0.05）。结论炎性因子参与了糖尿病肾病致病过程，为糖尿病肾病发生机制提供了理论基础。%Objective To analyze and discuss the changing characteristics of serum high-sensitivity C-reactive protein( hs-CRP) ,C-reactive protein( CRP) levels in the different stages of diabetic nephropathy . Methods Total of 100 patients with type 2 diabetes were selected in Guangxi Institute of Occupational Dis-ease Prevention and Control from Mar.2005 to Apr.2015,according to the urine protein/urine creatinine test results,the 100 patients were divided into simple diabetes group ( <30 mg/g,n=28 ) and diabetic nephrop-athy group(≥30 mg/g,n=72),and 30 healthy volunteers during the same period were included as a control group.hs-CRP and CRP levels were detected by immunofluorescence method .Results hs-CRP level of Sim-ple diabetes group swas (1.53 ±0.47) mg/L,CRP level was (7.23 ±1.13) mg/L;hs-CRP level of diabet-ic nephropathy group was (2.14 ±0.63) mg/L,CRP level was (19.35 ±4.12) mg/L;hs-CRP level of the healthy control group was (0.71 ±0.21) mg/L,CRP level was (1.91 ±0.34) mg/L.The hs-CRP and CRP level of diabetic nephropathy group were significantly higher than the diabetic group and healthy control group,the differences were statistically significant(P<0.05).With the increase of the level of proteinuria, serum hs-CRP and CRP levels also gradually increased (P<0.05).hs-CRP level of small amount proteinu-ria group was (1.70 ±0.31) mg/L,CRP level was (12.53 ±1.24) mg/L;hs-CRP level of medium amount proteinuria group was (2.39 ±0.32) mg/L,CRP level was (22.36 ±3.11) mg/L;hs-CRP level of Mac-roalbuminuria group was (2.91 ±0.47 ) mg/L, CRP level was ( 32.93 ±4.35 ) mg/L.The hs-CRP and CRP level of macroalbuminuria group were higher than the small amount proteinuria group and medium amount proteinuria group(P<0.05);and the medium amount proteinuria group was higher than the small amount proteinuria group(P <0.05).Conclusion The inflammatory cytokines are involved in the patho-genesis of diabetic osteopathy,providing a theoretical basis for diabetic nephropathy mechanisms.
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