Wilms肿瘤基因(WT1)是与Wilms肿瘤密切相关的癌基因,具有锌指转录因子活性.近年来研究表明,WT1基因是维持组织器官生长发育的重要调控因子;当WT1基因表达异常时,除了作为抑癌或原癌基因参与多种肿瘤发生发展外,还与肥胖、糖尿病、高血压等非肿瘤性疾病关系密切.本文主要就WT1基因在生长发育及非肿瘤性疾病发生中的作用综述如下.%The Wilms' tumor 1gene ( WT1) encodes a zinc finger transcription factor and is associated with wilms' tumor. Recent studies have shown that WT1 is indispensable for normal development of many organs and tissues. Besides acting as a tumor suppressor or proto-oncogene, WT1 is also closely related to many non-neoplastic diseases such as obesi-ty, diabetes and hypertension. This article mainly focuses on participation of WT1 gene in physiological development as well as in multiple diseases.
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