Objective: To analyze the Zhejiang city of birth defects and dynamics in the basic situation, seek to influence the city's main reason for birth defects and prevention strategies. Methods: Maternal and Child Health Hospital of Obstetrics city 2000-2010 Statistical analysis of birth defects. Results: 9458 cases of perinatal birth defects occurred in 216 patients, the total incidence of birth defects 28.86‰; birth defects. child mortality rate 3.62 ‰.The top five birth defects are cleft lip and palate, neural tube development defects. no brain child, congemtal heart disease, umbilical hemia; the incidence of birth defects is proportional to matemal age, 36 years old pregnant women are high risk factors ofbirth defects occur;The incidence of birth defects in rural areas than urban . Conclusions: Prenatal screening of pregnant women of childbearing age, pregnant women of childbearing age in rural areas and knowledge of universal care, prenatal and postnatal care ofwomen during pregnancy bearing age to create a favorable social and cultural environment of birth, in health policy and health insurance system to give moderate tiltreduce the incidence of birth defects.%目的:分析浙江省兰溪市围产儿出生缺陷的基本情况及动态变化,探索影响该市围产儿出生缺陷的主要原因和预防策略.方法:对2000-2010年兰溪市妇幼保健院产科出生缺陷资料进行统计分析.结果:9458例围产儿中发生出生缺陷216例,总出生缺陷发生率28.86‰;出生缺陷儿死亡率3.62‰.出生缺陷前五位的是唇腭裂、神经管发育畸形、无脑儿、先天性心脏病、脐疝;出生缺陷发生率与孕产妇年龄成正比,36岁以上孕妇是发生出生缺陷的高危因素;农村出生缺陷的发生率高于城市.结论:加强育龄孕妇产前筛查、农村育龄妇女孕期护理和相关知识的普及,降低围产儿的出生缺陷发生率.
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