Detailed knowledge of micro- or nano-size particle deposition in human respiratory tracts is an important issue in understanding the effect of exposure to pollutants in risk assessment as well as in assessing the efficacy of inhaled drug therapy. The complicated flow field can be simulated in realistic respiratory tract models with the help of computational fluid dynamics (CFD) simulation method and the resulting deposition profiles are more accurate. In this article, advances in the study of CFD, governing equations, and general steps in doing CFD simulation are reviewed.%不论是吸入危害评估还是药物气溶胶的靶向治疗,都需要了解气溶胶颗粒在呼吸道中的区域沉积特征.随着科技的进步,已经可以利用计算机流体动力学模拟技术(CFD)生成逼真的呼吸道模型,并在其中模拟复杂的气流传输特征,产生相对准确的沉降结果.该文综述了CFD模拟技术的研究进展,阐述了微米或纳米级颗粒沉降的主要公式和目前运用该方法 的一般步骤.
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