目的：探究癌胚抗原（CEA）、糖类抗原199（CA19-9）、糖类抗原724（CA72-4）在体检人群中的胃肠道肿瘤阳性预测值及其诊断价值。方法收集因体检发现CEA、CA72-4、CA19-9任意一项或多项升高而就诊的患者219例，通过胃肠镜检查判断有无胃肠道肿瘤，计算分析CEA、CA72-4、CA19-9的阳性预测值。结果 CEA、CA19-9、CA72-4在胃肠道肿瘤中的阳性预测值分别为4.17%，3.23%和0.00%。多项肿瘤标志物联合升高的阳性预测值显著高于单项肿瘤标志物升高（P=0.002）。且肿瘤标志物的阳性预测值与年龄及临床症状有关。结论 CEA、CA72-4、CA19-9在体检人群中的胃肠道肿瘤阳性预测值不高，但对于多项肿瘤标志物联合升高，年龄>40岁及合并临床症状的患者需提高警惕，进一步检查。%Objective To investigate the positive predictive value and diagnostic significance of serum tumor markers (CEA, CA19-9 and CA72-4) in gastrointestinal tumors in health check-up population. Meth-ods A total of 219 patients who had at least one of increased level of serum tumor markers (CEA, CA19-9 and CA72-4) were enrolled. Gastrointestinal tumors were detected by gastroscopy or colonoscopy, while the posi-tive predictive value of CEA, CA19-9 and CA72-4 was analyzed. Results The positive predictive values of CEA, CA19-9 and CA72-4 were 4.17%, 3.23%and 0%for gastrointestinal tumors, respectively. The value of combined three markers was significantly higher than single marker (P=0.002). Furthermore, the positive pre-dictive value of tumor markers was associated with age and clinical symptoms. Conclusions The positive pre-dictive value of CEA, CA19-9 and CA72-4 for gastrointestinal tumors is low in health check-up population. Further inspection is necessary for the patients who has multiple increased tumor markers and is over 40 years old.
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