In this paper, nanoscale pumpkin inositol extract (NPIE) was prepared,then its hypoglycemic effect was evaluated in Streptozocin (STZ)-induced diabetic mice and the effect compared to common pumpkin inositol extract (CPIE). The experiment was comprised of diabetic mice treated with the low- and high- dose (250 mg/kg and 500 mg/kg) of NPIE and CPIE, respectively, positive controls with Mefformin Hydrochloride (Met), and model group administrated with distilled water. The experiment term was 30 days. The results showed that the pumpkin extract contained 3.21％ inositol and 53.21％ polysaccharide,in which the average diameter of NPIE was leas than 500 nm. After animal experiment, all groups had no influence on the acute hypoglycemic effect of normal mice and the body weight of diabetic mice;however, a significantly reduced levels of the random and fasting blood glucose and a improvement in blood glucose tolerance were noticed in the diabetic mice treated with 500 mg/kg of NPIE. And the hypoglycemic effect of NPIE was slightly lower than Met,but higher than CPIE.%本文通过制备纳米级南瓜肌醇提取物(Nanoscale pumpkin inositol extract,NPIE),观察其对链脲佐菌素诱导的糖尿病模型C57小鼠的血糖调节作用,并与普通南瓜肌醇提取物(Common pumpkin inositol extract,CPIE)的降血糖作用比较.高、低剂量CPIE组和NPIE组分别灌胃500 mg/kg、250 mg/kg的CPIE和NPIE水溶液,阳性药组灌服250 mg/kg的盐酸二甲双胍水溶液,模型对照组灌服等体积的双蒸水,实验周期均为30 d.结果显示所制备的南瓜肌醇提取物含肌醇3.12%,多糖53.21%,其中NPIE粒度平均小于500 nm;经动物实验,各给药组对正常小鼠无明显急性降糖作用,对糖尿病小鼠体重也无影响;但NPIE高剂量组对糖尿病小鼠的随机血糖和空腹血糖均具有明显降低效果,并对其糖耐量有一定改善作用,整体降糖效果较阳性药物组略弱,较CPIE强.
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