Objectives To explore clinical implication of T c ell sub-group changes and peripheral blood SIL-2R of anaphylactoid purpura child ren.Methods Use ELISA to measure the level of peripheral blood S oluble Interleukin-2 receptor (SIL-2R)of HSP children,at the same time,use McAb to measure T cell sub-group.Results The serum levels SIL-2R was higher in acute phase that in control and lysis phase(P＜0.01,0. 0 5respectively),Although the levels of SIL-2R descened a little in lysis phase,st ill higher than that of control,and all of CD3、CD4、CD8 were lower in act ue p hase of HSP children than that of control.(P＜0.01，0.05 repectively),while the changeable proportion of CD4、CD8 in lysis group was different,which lead to a h igher ratio of CD4、CD8 (P＜0.05).Conclusions SIL-2R an d T cell sub-group may be adopted as reference index of diafnosis syndrome monitor and prognosis dete rmination of HSP.%目的 探讨过敏性紫癜患儿外周血SIL- 2R和T细胞亚群变化的临床意义。方法 采用双抗体夹心法ELISA法测定过敏性紫癜(HSP)患儿外周血可溶性白细胞介素-2受体(SIL-2R)水平，同时用McAb法检测T细胞亚群。结果 急性期HSP患儿血清SIL-2R水平较对照组和缓解组明显提高(P分别＜0.01和0.05)，缓解组SIL-2R虽有所下降但仍明显高于对照组( P＜0.05)，并且HSP急性期患儿CD3、CD4、CD8均显著低于对照组(P分别＜0 .01和0.05)，而在缓解组CD3、CD4、CD8均向正常方向转化，但仍然偏低。由于CD 4、CD8的变化比例不同，结果导致CD4、CD8比例明显升高(P＜0.05)。结论 SIL-2R和T细胞亚群可作为HSP诊断、病情监测及预后判断的参考性指标。
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