This paper studies the mineral processing of a silver-containing poly-metallic sulfide ore. The process mineralogy results show complex mineral components and closely-associated minerals. Copper-lead-zinc preferential flotation processing is applied by using Z-200 as copper preferential flotation collector, QF-11 as lead preferential flotation collector, CuSO 4 as zinc activator, butyl xanthate as zinc collector. The closed-circuit tests showed that the copper concentrate of 20.02 % Cu with a recovery rate of 69.30 %, containing silver 8 150.32 g/t, silver recovery rate of 55.01 % are obtained. The lead concentrate of 55.01 %Pb with a recovery rate of 81.86 %, containing silver 2 400 g/t, silver recovery rate of 37.80 %, the zinc concentrate of 50.56 % Zn with a recovery rate of 81.28 % are also obtained. QF-11 has good lead preferential flotation in low alkali. The application of QF-11 as lead collector in lead flotation is favorable for silver enrichment in lead concentrate, which in turn increases the recovery rate of associated silver. In addition, it can avoid using large amount of lime in lead processing.% 对某含银多金属硫化矿进行选矿试验研究.工艺矿物学研究表明：矿石中矿物组分复杂、矿物之间共生紧密，采用Z-200优先选铜，铜尾矿用QF-11优先选铅，铅尾矿经硫酸铜活化后，用丁黄药选锌的浮选工艺流程，可获得含铜20.02%、铜回收率69.30%、含银8150.32 g/t、银回收率55.01%的铜精矿，含铅55.70%、铅回收率81.86%、含银2400 g/t、银回收率37.80%的铅精矿，含锌50.56%、锌回收率81.26%的锌精矿.QF-11在低碱度条件下对铅矿物选择性较好，在选铅作业中，使用QF-11作为铅捕收剂，不仅可以避免使用大量石灰，也有利于贵金属银在铅精矿中的富集，提高伴生银的回收率.
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