目的：研究盐酸头孢吡肟在小鼠肺组织内的药动学特征。方法小鼠尾静脉注射盐酸头孢吡肟后，于不同时间点取小鼠肺组织并以 HPLC 测定肺内药物含量，采用 DAS3．1软件处理，计算药动学参数并进行统计学分析。结果小鼠肺内盐酸头孢吡肟的主要药动学参数 t1/2为0．267 h ，Cmax 为20．279μg ・ g -1，AUC0～ t为9．897μg ・ h ・ g -1，MRT0～ t为1．954 h 。结论小鼠尾静脉注射盐酸头孢吡肟后，在肺组织内分布较快，呈一室模型，提示盐酸头孢吡肟静脉给药能有效治疗敏感菌引起的肺部感染。%Objective To study the pharmacokinetic profile of cefepime hydrochloride in mice lung .Methods Lung samples were col-lected at different time points after caudal vein administration of cefepime hydrochloride at single bolus dose .The drug concentra-tion was determined by HPLC ,and the pharmacokinetic parameters were calculated by DAS3 .1 pharmacokinetic program .Results The main pharmacokinetic parameters of cefepime hydrochloride in mice lung were shown as follows :t1/2 0 .267 h ,Cmax 20 .279 μg ・ g - 1 , AUC0 ~ t 9 .897 μg ・ h ・ g - 1 ,and MRT0 ~ t 1 .954 h .The distribution of cefepime hydrochloride was extremely fast in mice lung after drug administration ,demonstrating the kinetics of a one-compartment model . Conclusion These results indicated that cefepime hydrochloride via peripheral intravenous admininstraion is effective to cure the lung infection disease .
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