Microfabrication,surface modification,and laser guidance techniques to create a neuron biochip

Russell Kirk Pirlo; Xiang Peng; Xiaocong Yuan; Bruce Zhi Gao

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Microfabrication,surface modification,and laser guidance techniques to create a neuron biochip

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In this report we illustrate our application of soft lithography-based microfabrication,surface modification,and our unique laser cell-patterning system toward the creation of neuron biochips. We deposited individual forebrain neurons from Day 7 embryonic chicks into two rows of eight in a silicon microstructure aligned over a microelectrode array (MEA). The polydimethylsiloxane (PDMS) membrane with microstructures to confine cells and guide network connectivity was aligned to the electrodes of a MEA. Both the MEA and the PDMS membrane were treated with O2 plasma,Poly-L-Lysine,and Laminin to aid in cell attachment and survival. The primary advantage of our process is that it is quicker and simpler than previous cell-placement methods and may make highly defined neuronal network biochips more practical.

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《光电子快报：英文版》 |2008年第5期|387-390|共4页
作者
Russell Kirk Pirlo; Xiang Peng; Xiaocong Yuan; Bruce Zhi Gao;
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作者单位

Department of Bioengineering and Center for Optical Materials Science and Engineering Technologies;

Clemson University;

Clemson;

SC 29634;

USA;

Institute of Optoelectronics;

Shenzhen University;

Shenzhen 518060;

China;

School of Electrical ＆ Electronic Engineering;

Nanyang Technological University;

Nanyang Avenue;

Singapore 639798;

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原文格式 PDF
正文语种 chi
中图分类光、激光生物医学;
关键词
表面处理技术; 激光器指导技术; 神经元; 生物芯片;

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Microfabrication,surface modification,and laser guidance techniques to create a neuron biochip

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